Protein is a kind of common biological macromolecule, which plays an important role in life activities. It is very necessary to study protein structure, evolution or key residues in protein from a global perspective. The protein molecule is transformed into an amino acid interaction network with amino acids as nodes and their interactions as edges. The complex network theory is used to analyze, which provides a new perspective for the study of protein-related issues.
The three-dimensional structure of a protein can also be transformed into an undirected network, with the amino acids constituting the protein as the nodes and the interaction between amino acids as the edges. This kind of network is called amino acid interaction network (Amino Acids Network, AAN), residue interaction network (Residues Interaction Network, RIN) or protein structure network ((Protein Structure Network, PSN). Here, we named this type of network after amino acid interaction network in order to distinguish it from protein interaction network. Studying protein from the perspective of network can better study its topological properties and the overall connectivity of each component in the protein molecule.
CD ComputaBio has many years of experience in the research of biological complex networks. In the past years, we have worked with many research institutes and pharmaceutical companies to solve problems related to complex networks for customers. We can provide you with the following services but not limited to:
|Complex network analysis service
|CD ComputaBio uses RINs analysis to provide you with professional complex analysis of proteins and their complexes, predict the different properties and functions of individual residues and the entire protein, and analyze the chemical and physical properties of bases and the energy of their interaction through the construction of RIN . In addition, CD ComputaBio can also provide you with analysis of the nature of the network.
|Depends on the time you need to simulate and the time required for the system to reach equilibrium.
|Product delivery mode
|The simulation results provide you with the raw data and analysis results of molecular dynamics.
CD ComputaBio provides corresponding professional amino acid network services. Our residue interaction service has proven to be very useful for understanding the biochemical basis of physiological events at different stages of drug development (even in different fields such as materials science). The CD ComputaBio team has worked in this field for more than a decade and published his findings in top scientific journals. If you need network analysis services, please feel free to contact us.
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