MicroRNA and Target Gene Network Diagram

MicroRNAs are a class of short non-coding RNAs of 18 to 24 nucleotides in length that post-transcriptionally regulate various target genes which involving in a variety of biological processes such as cell cycle, differentiation, cell proliferation, and apoptosis.At the transcriptional level, transcription factors (TFs) has been considered as the primary regulator to control the gene expression.Recent studies show that transcription factors regulate the expression of miRNA, and participate in a variety of biological processes including tumorigenesis. MicroRNA and target gene network diagram is to take the significant function and the target gene contained in the significant pathway to construct a microRNA target gene regulatory network with microRNA, which can intuitively reflect the relationship between genes on a global level, and reflect at the same time The stability of the gene regulatory network. According to the position function of the microRNA in the network, the relationship strength of the microRNA in the network is calculated, that is, the network characteristic value of the microRNA. High eigenvalue microRNA is in the pivotal position of the network. This microRNA has strong regulatory capabilities and has important regulatory value for network structure and sample characteristics. At the same time, key target genes regulated by microRNA can be obtained from the network.

Figure 1 MicroRNA expression and function (Ramiro Garzon et al. 2006)

Our solutions

CD ComputaBio looks for target genes contained in important pathways, and then uses microRNA to construct a microRNA target gene regulatory network. The network we provide can intuitively reflect the relationship between global genes.
CD ComputaBio provides microRNA and target gene network maps to reflect the stability of gene regulatory networks.
CD ComputaBio can calculate the correlation strength of the microRNA in the network according to the position function of the microRNA in the network, that is, the network characteristic value of the microRNA.
CD ComputaBio can find microRNAs with high eigenvalues at key positions in the network. MicroRNA has a strong ability to regulate, and has important regulatory value for network structure and sample characteristics. At the same time, key target genes regulated by microRNA can be obtained from the network.

Services items

Project name	MicroRNA and target gene network diagram
Advantages	miRNA is a hot research topic in recent years. Mastering MicroRNA and target gene network diagram is not only conducive to research, but also can greatly save scientific research time. The reasonable construction of regulatory network models in the fields of computer and other fields through later experimental verification is expected to discover new regulatory pathways and laws from multiple angles and levels, providing meaningful theoretical and experimental basis for the development of disciplines and disease treatment.
Cycle	Depends on the time you need to simulate and the time required for the system to reach equilibrium.
Product delivery mode	The simulation results provide you with the raw data and analysis results of molecular dynamics.
Price	Inquiry

CD ComputaBio provides corresponding professional microRNA and target gene network diagram. Our microRNA and target gene network diagram has proven to be very useful for understanding the biochemical basis of physiological events at different stages of drug development. The CD ComputaBio team has worked in this field for more than a decade and published his findings in top scientific journals. If you need network analysis services, please feel free to contact us.

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