Protein Structure Prediction

The prediction of protein secondary structure is generally regarded as the first step of protein structure prediction. Secondary structure refers to regular protein local structural elements such as α helix and β sheet. Different amino acid residues have different propensities to form different secondary structure elements. According to the components of the secondary structure of the protein, the globular proteins can be divided into four folding types: all α protein, all β protein, α + β protein and α/β protein. Most of the algorithms for predicting the secondary structure of proteins are based on proteins with known three-dimensional structures and secondary structures, and have used artificial neural networks, genetic algorithms and other technologies to construct prediction methods.

Overall solutions

• SOPMA prediction

The protein sequence predicted by SOPMA mainly contains Alpha helix, Extended strand, Beta turn and Random coil.

• JPred prediction

The algorithm that JPred used at the beginning was a large-scale comparison analysis, and later it used a neural network method.

• GOR prediction

GOR is a method based on information theory and Bayesian statistics. The name of the method is a combination of the first letters of the names of three inventors (Garnier, Osguthorpe, Robson). GOR treats the protein sequence as a series of information values. The GOR method not only considers the influence of the type of amino acid residues in the predicted position, but also the influence of the types of adjacent residues on the conformation of the position.

Other algorithms

Prediction based on statistics and machine learning methods:

• Chou-Fasman algorithm
• PHD algorithm(prediction of typical transmembrane spiral area)
• Multi-series nomination forecast
• Sequence prediction based on neural network
• Prediction method based on existing knowledge (knowledge based method)
• Hybrid system method

Our advantages

• The team of CD ComputaBio has a wealth of knowledge and experience. We work with many from all over the world, and our service quality is guaranteed.
• Our research supervisor and project manager will complete your project on time through open communication channels and meet your requirements.
• CD ComputaBio has established a professional after-sales service team to provide customers with efficient, fast and practical solutions.

Services items

CD ComputaBio's protein structure prediction service can reduce the cost of subsequent experiments. Protein structure prediction service is an important and necessary step in the process of drug discovery and development. Protein structure prediction service is a personalized and customized innovative scientific research service. Before determining the corresponding analysis plan and price, each project needs to be evaluated. If you want to know more about service prices or technical details, please feel free to contact us.