Membrane Protein Modeling Service

About 20%-30% of genes in the genome of organisms encode membrane proteins. Membrane proteins play a key role in a variety of cellular functions, such as ligand-receptor binding, signal transduction, molecular transport, intercellular recognition, and cellular adhesion and so on. At present, in the fields of biological research and drug development, there is an increasing demand for membrane proteins as targets. The successful preparation of membrane protein is an important prerequisite for obtaining powerful anti-membrane protein antibodies. Since most membrane proteins are partially or completely embedded in the lipid bilayer, conventional protein expression methods may have some obstacles in the preparation of membrane proteins, such as low expression levels, relatively difficult extraction, possible misfolding, and incomplete translation after modification and so on.

Figure 1. Member prorein.

Overall solutions

CD ComputaBio can provide you with professional membrane protein construction services:

Based on years of project experience, CD ComputaBio has fully researched and explored the key difficulties of membrane protein modeling. By integrating various advanced technologies, we strive to effectively complete a variety of membrane protein modeling projects through various development strategies to overcome the main difficulties in membrane protein modeling.
CD ComputaBio uses traditional homology modeling methods to predict the structure of membrane proteins, thereby avoiding any deviations in the soluble globular protein algorithm and obtaining better modeling results.
In the absence of structural information from closely related proteins, distant structural homologs can be used to reconstruct the core and loop regions.
Over the years, we have accumulated rich experience in modeling various types of membrane proteins, including G protein coupled receptors (GPCRs) and transporters. The generated structural models have been quality-verified and can be used for drug design calculations, molecular dynamics simulations, and to guide further experimental work, such as structure-based protein engineering.

Services items

Project name	Membrane Protein Modeling Service
Our features	Because there are too few membrane receptor proteins with known three-dimensional structures, structures based on knowledge modeling are unreliable and subjective. With the accumulation of membrane protein structure data and the improvement of computer modeling methods, computational modeling will inevitably become more mature, and the construction of 3D structures will be more reliable. Once the three-dimensional structure model of the membrane receptor protein is obtained, it can be further inverted to guide experimental research, such as receptor site mutation and drug design based on receptor structure. Our advantage: Computer modeling saves a lot of labor costs. Efficient 3D construction. The funds required are far less than biological or chemical experiments. High-precision modeling. Supports multi-chain membrane proteins. A membrane protein model embedded in a lipid bilayer. Quality assessment is carried out through multiple standards.
Cycle	Depends on the time you need to simulate and the time required for the system to reach equilibrium.
Product delivery mode	The simulation results provide you with the raw data and analysis results of molecular dynamics.
Price	Inquiry

CD ComputaBio's membrane protein modeling service can reduce the cost of subsequent experiments. Membrane protein modeling service is a personalized and customized innovative scientific research service. Before determining the corresponding analysis plan and price, each project needs to be evaluated. If you want to know more about service prices or technical details, please feel free to contact us. If you want to know more about service prices or technical details, please feel free to contact us.

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