Protein folding is the process by which a protein obtains its functional structure and conformation. Through this physical process, the protein folds from random coils into a specific functional three-dimensional structure. When translating from an mRNA sequence into a linear peptide chain, the protein exists in the form of an unfolded polypeptide or a random coil. The clarification of the protein folding mechanism will reveal the second set of genetic codes in life, which is its theoretical significance. The study of protein folding, in a narrower sense, is to study the formation of a specific three-dimensional structure of a protein, its stability, and its relationship with its biological activity. The problem of protein folding is listed as an important subject of "Biophysics in the 21st Century", and it is a major biological problem that has not been resolved by the Central Law of Molecular Biology. Predicting the tertiary structure of a protein molecule from the primary sequence and further predicting its function is an extremely challenging task. The study of protein folding, especially the early folding process, that is, the folding process of new peptides, is a fundamental issue for the comprehensive and final elucidation of the central principle.
Figure 1. Protein folding.
Protein folding recognition is a hot issue in bioinformatics in recent years. Through protein folding recognition, the structure and function of unknown proteins can be preliminarily inferred. The task of fold recognition is to find out the fold type to which the unknown protein belongs. Further inferring the structure and function of the unknown protein according to the superfamily and folding class to which it belongs. In the study of protein folding recognition, the main research methods are divided into three categories: methods based on comparison, methods based on machine learning, and methods based on ensemble.
|Fold Recognition Service
CD ComputaBio provides expertise to help identify the correct structural fold in the known template protein structure of the target protein by combining sequence diagram alignment with a variety of structural information.
|Depends on the time you need to simulate and the time required for the system to reach equilibrium.
|Product delivery mode
|The simulation results provide you with the raw data and analysis results of molecular dynamics.
CD ComputaBio's fold recognition service can reduce the cost of subsequent experiments. Fold recognition service is a personalized and customized innovative scientific research service. Before determining the corresponding analysis plan and price, each project needs to be evaluated. If you want to know more about service prices or technical details, please feel free to contact us. If you want to know more about service prices or technical details, please feel free to contact us.
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