AI-Assisted Biocatalytic Element Design

What is Biocatalytic Element?

Biocatalysts are biological molecules or cells that can catalyze chemical reactions and are widely used in industrial processes for the production of important compounds. These biocatalysts can be enzymes, microorganisms, or even whole cells that have been engineered to perform specific reactions efficiently. One of the key advantages of biocatalysts is their environmental friendliness. Unlike traditional chemical catalysts, biocatalysts are derived from renewable resources and operate under mild conditions, which can significantly reduce energy consumption and environmental impact.

Fig 1: Computational tools for the evaluation of laboratory-engineered biocatalysts. (Romero-Rivera A, et al, 2017)

Our Services

• Computational Modeling and Simulation
  Our team utilizes advanced computational modeling and simulation tools to predict and optimize the performance of biocatalysts. By leveraging AI algorithms, we can accurately predict the behavior of biocatalysts under different conditions and design highly efficient enzymes or microorganisms for specific applications.
• Designed from Scratch
  Our scientists use the inside-out strategy to design catalytic components from scratch, first designing the active site and then designing the backbone protein. Using enzyme sequences in sequence databases for direct coupling analysis (DCA), our scientists also generated a series of artificially designed sequences based on statistical models.
• Increasing Enzyme Stability
  Naturally evolved enzymes are often unable to tolerate high temperatures, high salts, or high concentrations of organic solvents, so methods to rapidly improve stability without losing their activity are urgently needed. Our scientists designed a stable framework based on the selectivity and other properties of the modified enzyme to tolerate the possible loss of stability caused by activity-enhancing mutations.

Types of Our Biocatalysts

Several types of biocatalysts can be designed and optimized for various applications:

CD ComputaBio offers a comprehensive AI-assisted biocatalysts design service to enable our clients to optimize their bioprocesses and enhance the production of valuable compounds. With our expertise in computational modeling, enzyme engineering, microorganism design, and bioprocess optimization, we are dedicated to delivering customized solutions that meet the specific needs of our clients. If you are interested in our services or have any questions, please feel free to contact us.