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PK/PD Prediction

At CD ComputaBio, we specialize in providing cutting-edge pharmacokinetics (PK) and pharmacodynamics (PD) prediction services to streamline drug development processes. Our advanced AI methods enable us to deliver precise and reliable predictions that support your research and development efforts. With a mission to enhance the efficiency and accuracy of drug discovery, our team of experts leverages state-of-the-art technologies to ensure you achieve your project goals.

Introduction to PK/PD Modeling

The PK/PD model integrates variables (like time, effect, etc.) and variation factors (such as gender, age, etc.) through modeling, sets the dose and degree of variation, fits the obtained data, and reveals the effects of drug by obtaining various parameters, as well as the changing characteristics of the process. The PK/PD modeling is helpful for drug screening and accelerates the process of new drug development.

Our Services

CD ComputaBio utilizes AI for advanced drug crystal form prediction, aiding pharmaceutical firms and research institutions in drug development, formulation strategies, and reducing crystal form variability risks.

Drug PK/PD model

Comprehensive PK Simulation

  • Absorption Models - Understanding the absorption rates of orally administered drugs.
  • Distribution Analysis - Evaluating how a drug disperses throughout bodily tissues.
  • Metabolism Prediction - Predicting the metabolic pathways and clearance rates.

Drug PK/PD analysis

Integrated PK/PD Modeling

  • Physiologically Based Pharmacokinetics (PBPK) - Simulating drug behavior using physiological parameters.
  • Simulations for Various Conditions - Creating models to predict drug behavior in specific populations, such as pediatrics or elderly patients.

Custom model

Custom Model Development

Recognizing that each project has unique requirements, we provide PK/PD model development tailored to your specific needs, ensuring satisfactory results

PK/PD Modeling Process

Due to advances in pharmacokinetic analysis software and computer technology, the methodology of PK/PD model establishment has progressed significantly. The modeling methodology research involves five steps:

Phase 1 Initially determine the experimental model based on pre-test results for dose and pharmacodynamic indices. Establish the "concentration-effect" relationship and a preliminary "dose-effect" model.
Phase 2 Design experiments to define drug dosage, sampling times, and monitoring periods.
Phase 3 Collect data during formal experiments.
Phase 4 Preliminary analysis of experimental data through concentration-time, effect-time, and concentration-effect plots.
Phase 5 Verify and refine the model determined during the pre-test.

Result Delivery

  • Timeline
    Standard Projects - Typically completed within 2 to 3 weeks, depending on project complexity and scope.
  • Reporting
    You will receive a detailed report upon completion of our analysis.
    • Executive Summary: A concise overview of the findings and implications.
    • Methodology: Detailed descriptions of the models and methods utilized.
    • Results Section: Comprehensive presentation of data, including graphs and tables.

At CD ComputaBio, we offer comprehensive PK/PD prediction services, leveraging advanced AI and computational modeling to provide insights that facilitate drug development and optimization. Our aim is to help research organizations, pharmaceutical companies, and biotech firms make informed decisions throughout the drug discovery process. If you are interested in our services or have any questions, please feel free to contact us.

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