At CD ComputaBio, we specialize in advancing biopharmaceutical research through innovative computer simulations and expert services. Among our cutting-edge offerings, antibody affinity maturation stands out as a critical process for enhancing the binding strength and specificity of antibodies.
Therapeutic Antibodies
Affinity maturation is fundamental in the development of therapeutic antibodies, enhancing their efficacy in treating diseases. Improved binding affinity can lead to:
Diagnostic Tools
High-affinity antibodies are essential for precise detection in various diagnostic applications, including:
Computational Modeling
Using advanced computational tools, our experts perform simulations to predict mutations that could enhance affinity.
Fig 1. Generalized workflow of antibody modeling.
Mutagenesis and Library Construction
Following computational predictions, we construct a library of mutated variants based on the identified hotspots.
Fig 2. Antibody modeling
Molecular Dynamics (MD) Simulations
Utilizing advanced MD simulations to model the interactions between antibodies and antigens, allowing us to predict binding affinities and identify key residue interactions.
Docking Studies
Implementing state-of-the-art docking algorithms to predict how well an antibody binds to its target. We analyze conformational flexibility to ascertain the best binding conformations.
Affinity Comparison
We compare the developed antibody variants against benchmark antibodies and their known affinities to provide a clear context for the improvements achieved through our maturation process.
| Service Details | Deliverables | Lead Time |
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Depends on the time you need to simulate and the time required for the system to reach equilibrium. |
CD ComputaBio is at the forefront of biopharmaceutical development, offering cutting-edge services in antibody affinity maturation. Our advanced computer simulation techniques enable precise optimization of antibody interactions, providing our clients with high-affinity antibodies tailored to their specific research needs. This page outlines our services, sample requirements, analysis methods, and results delivery process. If you are interested in our services or have any questions, please feel free to contact us.
Services