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Ligand-based Target Prediction

Welcome to CD ComputaBio, where we specialize in advanced ligand-based target prediction services designed for researchers, pharmaceutical companies, and biotechnology firms. Our suite of services utilizes state-of-the-art artificial intelligence (AI) methodologies to facilitate drug discovery and development processes. With our innovative technology and expert insights, we provide a comprehensive approach to predicting potential biological targets for your ligand molecules.

Our Services

At CD ComputaBio, we offer an extensive range of ligand-based target prediction services tailored to meet the diverse needs of our clients. These services are crucial for identifying potential targets in various therapeutic areas, aiding in drug repurposing, and accelerating the overall drug discovery workflow.

Ligand structure

Ligand Efficiency Prediction

We evaluate the efficiency of ligands concerning their target interactions. This service employs various metrics to quantify binding potency and provides insights necessary for lead optimization.

Virtual screening

Compound Screening

We offer a virtual screening of compound libraries using ligand-based methods to identify promising candidates for further development. This service helps in recognizing lead compounds that exhibit high affinity and specificity for biological targets.

SAR modeling

Structure-Activity Relationship (SAR) Modeling

Our SAR modeling service provides insights into the relationship between the chemical structure of ligands and their biological activity. By analyzing data on similar compounds, we can help you design new ligands with improved efficacy.

Off-targets

Prediction of Off-Targets

Understanding off-target interactions is essential to minimize side effects in drug development. Our services include predictive modeling to assess potential off-target activities, thus aiding in the refinement of lead candidates.

Analysis Methods

Pharmacophore Modeling

Pharmacophore modeling identifies the structural features in ligands that are critical for biological activity. Our AI algorithms analyze known ligands and their binding modes to create pharmacophore models that serve as templates for identifying potential targets.

Molecular Docking

We utilize molecular docking techniques that simulate the interaction between ligands and their potential biological targets. By predicting binding affinities and modes of action, we can identify how a ligand will interact with protein targets at the atomic level.

Machine Learning Algorithms

Machine learning plays a crucial role in our predictive models. Using supervised and unsupervised learning techniques, we analyze datasets of known ligand-target interactions to train models that can predict targets for novel ligands.

Strategies of Pharmacophore Modeling

  • Comparative Molecular Field Analysis (CoMFA) - Using the 3D quantitative structure-activity relationship (3D-QSAR) method of ligands, the pharmacophore model is constructed by comparing the molecular fields of different compounds.
  • Comparative Molecular Similarity Analysis (CoMSIA) - Building on CoMFA, molecular similarity analysis is added to consider factors such as hydrophobicity and charge distribution.
  • Hybrid Methods -These methods comprehensively utilize the advantages of both ligand-based and structure-based approaches to form a more reliable and comprehensive pharmacophore model.

Sample Requirements

Chemical Structure
  • Format - Submit chemical structures in common formats such as SMILES, SDF, or Mol files.
  • Data Completeness - Provide information on all relevant functional groups and stereochemistry, as these factors hugely influence interaction predictions.
Compound Data
  • Ligand Information - Include comprehensive data on the ligands to be evaluated, including known activity and any existing target interactions, if available.
  • Concentration Levels - Information on concentrations and bioactivity (e.g., IC50, Ki) helps improve the accuracy of the predictions.

Our Advantages

Comprehensive Services

From initial data analysis to interpretation of results, our comprehensive services cover every aspect of ligand-based target prediction.

Customizable Solutions

Our services can be tailored to meet specific requirements, ensuring that the solutions we provide are aligned with your objectives.

Quality Assurance

We adhere to rigorous quality assurance protocols to ensure the accuracy and reliability of our predictions.

At CD ComputaBio, our team consists of seasoned bioinformatics professionals with extensive experience in cheminformatics, molecular modeling, and machine learning. We leverage our knowledge to provide reliable and actionable insights that enhance your research endeavors. If you are interested in our services or have any questions, please feel free to contact us.

Services

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