Toxicology

Drug toxicity, especially hepatotoxicity, liver toxicity and cardiotoxicity, is a key reason for withdrawal of approved drugs from the market. It can save both time and developmental costs to identify potential toxicity at an early stage in drug discovery. Our toxicology services provide an extensive characterization of potential compound liabilities due to cardiac safety, hepatotoxicity, genotoxicity, safety pharmacology, and more. Our in vitro toxicology testing services are designed in accordance with international guidelines. In the meanwhile, developing novel in vitro toxicology assays for profiling and screening applications using new approaches and technologies, is proving to be valuable for evaluating emerging in vitro toxicology endpoints.

Numerous data exist online that can assist in in silico chemical or drug safety assessment. Capturing a chemical's safety profiles or toxicity within databases has become a necessary part of research across many industrial sectors, especially pharmaceuticals. CD ComputaBio is dedicating to integrating in silico data resources relevant to toxicology suitability for modelling, read-across, or similarity searching.

Toxicity Markers

Cell viability
Apoptosis
Reactive oxygen species generation
Steatosis and phospholipidosis
Cholestasis
Fibrosis
Mitochondrial function
Glutathione depletion

A comprehensive portfolio of in vitro toxicology assays include:

• Screening assays for key biochemical and biomarker endpoints of toxicity
• Testing using validated model systems for specific adverse outcome pathways
• Advanced 3D tissue models (3D Microtissue, Organoids, and Spheroid Models) designed to assess specific target organ liabilities
• Assays used in combination as part of an integrated toxicity assessment strategy: standard, custom, high throughput, and High Content Analysis (HCA) assays to evaluate multiple endpoints including cytotoxicity, mitochondrial toxicity, oxidative stress, apoptosis, phospholipidosis, and more.
• Custom mechanistic assays designed to identify novel adverse outcome pathways

CD ComputaBio provides comprehensive in vitro toxicology services to assess drug safety profiles early in the discovery process, and offers analytical services in support of toxicology studies, such as method validation, formulation analysis, homogeneity and stability testing. We serve producers of traditional pharmaceuticals, biopharmaceuticals, medical devices, gene therapies, industrial chemicals, and consumer products. All services can be ordered individually or combined.